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KMID : 0604520220480020097
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 2 p.97 ~ p.104
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Anti-inflammatory and Anti-oxidative Activities for the Subcritical Water Extract of Camellia japonica Flowers
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Kim Jung-Eun
Ko Ye-Rin
Boo Suk-Hwan
Kang Sung-Hee
Kang Sung-Hee
Lee Nam-Ho
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Abstract
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In this study, the anti-inflammatory and anti-oxidant efficacy of camellia subcritical water extracts (SWE, 135 ∼ 180 °C, 70 bar) was compared with 70% ethanol and hot water extracts. Among these extracts, the yield (57.9%) of the subcritical water extract, which was extracted under the condition of 180 °C and 70 bar was the highest, which increased the extraction yield by more than two times compared to the hot water extract (28.1%). The results of the nitric oxide (NO) production inhibition activity experiment using RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) showed that subcritical water extracts had superior effects in inhibiting the production of NO without cytotoxicity than 70% ethanol and hot water extracts. In addition, DPPH and ABTS+ radical scavenging activity experiments showed that the radical scavenging activity of subcritical water extract was similar to that of 70% ethanol and hot water extract. Moreover, the content of gallic acid was determined by HPLC and the quantity was about 1.62 mg/g for the SWE (165 °C, 70 bar), which was the highest among all of the extracts. Based on these results, it is concluded the SWE of C. japonica flowers could be potentially applicable as anti-inflammatory and anti-oxidative ingredients in cosmetic formulations.
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KEYWORD
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Camellia japonica, subcritical water extract, anti-inflammation, anti-oxidation
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